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KMID : 0624620220550090413
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BMB Reports
2022 Volume.55 No. 9 p.413 ~ p.416
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Mass spectrometry-based approaches to explore metabolism regulating ferroptosis
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Nguyen Chi Thi Ngoc
Kim Seon-Min
Kang Yun-Pyo
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Abstract
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Ferroptosis is a type of programmed cell death distinct from apoptosis or necroptosis. Ferroptosis is well characterized by an iron-dependent accumulation of lipid peroxides and disruption of cellular membrane integrity. Many metabolic alterations can prevent or accelerate ferroptosis induction. Recent advances in analytical techniques of mass spectrometry have allowed high-throughput analysis of metabolites known to be critical for understanding ferroptosis regulatory metabolism. In this review, we introduce mass spectrometry-based analytical methods contributing to recent discovery of various metabolic pathways regulating ferroptosis, focusing on cysteine metabolism, antioxidant metabolism, and poly-unsaturated fatty acid metabolism.
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KEYWORD
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Analytical method, Ferroptosis, Mass spectrometry
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